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Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014

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Men who have plateaued on semaglutide may benefit from adding cagrilintide's distinct mechanism

It is accompanied by cardiovascular benefits, including significant blood pressure reduction, lipid improvements, and dramatic weight loss, that almost certainly produce a net positive cardiovascular effect