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For diabetes management, alternatives include SGLT-2 inhibitors, DPP-4 inhibitors (which should not be combined with GLP-1 medications), metformin, and insulin when necessary
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Patients already experiencing side effects from Zepbound may notice worsening symptoms when berberine is added
The SELECT trial showed a 20% reduction in MACE in people with obesity but without diabetes
Semaglutide can be an effective tool for weight loss when used correctly
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