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Anthracycline-based FAC and FEC regimens demonstrate Level 1 evidence through Phase III trials, with GEICAM showing superior disease-free survival in 985 women and EBCTCG meta-analyses confirming 38% mortality reduction in women under 50 years, establishing it as adjuvant standard despite manageable cardiotoxicity

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It is not a GHRH analog it is a ghrelin mimetic, meaning it binds the ghrelin receptor (the same receptor activated by the hunger hormone)