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For instance, in NSCLC, treatment with first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) often leads to the development of the EGFR T790M mutation, while third-generation inhibitors subsequently select for the C797S mutation, both of which confer resistance

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Nuclei were stained purple, and those with a minor axis length of more than 4 m were counted as cells with round nuclei

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