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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0
Peptides discussed may be used off-label (meaning for purposes other than their FDA-approved indications)
Understanding HPLC (Purity) High-Performance Liquid Chromatography measures how pure the sample is
Timing and consistency matter more than any single intervention
The clinical trial protocol allowed for dose delays when side effects were intolerable
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