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10.1007/s11103-016-0531-2 80 KirlyL.KnstlerA.HllerK.FattingerM.JuhszC.MllerM.et al

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It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances ( Subclinical B12 deficiency, however, is far more prevalent, affecting up to 26% of the general population

In a presentation (PDF) to investors, Zealand notes that nearly 70% of clinical trial participants on the highest dose reported no gastrointestinal adverse events at any time