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Many of the cardiovascular and metabolic trials informing the discussion were not designed to evaluate ophthalmic outcomes. The authors called for prospective ophthalmology-specific studies incorporating imaging biomarkers, visual outcomes and disease-specific monitoring, noting that parsing the protective benefits or adverse effects of this rapidly growing medication class will be essential to refining disease management and improve patient outcomes. As GLP-1 therapies become increasingly common among patients with diabetes, obesity and vascular comorbiditiesprecisely the populations populating ophthalmic clinicsthe field may not have the luxury of waiting for cleaner data

What is new is the speed and magnitude of weight loss that GLP-1 medications produce

Evidence from the STEP 1 trial In a double-blind trial involving 1961 adults with obesity or overweight without diabetes, once-weekly semaglutide 2.4 mg combined with lifestyle intervention produced substantially greater weight loss than placebo over 68 weeks

It is traditional to look to medical charities such as the Gates Foundation or the Wellcome Trust for health-related initiatives