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Obesity affects about a third of adult Hoosiers
Weight reduction itself provides cardiovascular benefits and can improve overall quality of life for many people
It demonstrates exceptional efficacy in: Reducing appetite Improving blood sugar control Increasing fat loss Lowering the risk of health conditions like high blood pressure and high cholesterol
New options like retatrutide and orforglipron may be stronger, but they wont be widely available for several years
Obesity-associated adipose tissue thus functions as an inflammatory endocrine organ, particularly in visceral tissue producing TNF-, IL-6, IL-1, Monocyte chemoattractant Protein 1 (MCP-1, which is associated with tamoxifen resistance), and leptin while reducing adiponectin (an anti-inflammatory adipokine) levels, thereby promoting chronic low-grade inflammation, insulin resistance, and tumor-promoting signaling pathways
