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Animal care and use All experiments involving animals were conducted in strict accordance with the recommendations in the Guidelines for Proper Conduct of Animal Experiments published by the Science Council of Japan and ethics approvals from the Kyushu University Institutional Review Board (approval No

Severe gastrointestinal adverse reactions may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment, requiring close monitoring of fluid status and kidney function

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Species-specific factors profoundly influence both efficacy and safety profiles across all four peptide components