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Additionally, a polymeric CXCR4 antagonist (PCX) complexed with p53 siRNA (PCX/sip53) combines gene silencing with CXCR4 blockade, achieving simultaneous inhibition of apoptosis and inflammatory cell recruitment in cisplatin and bilateral IRI models while avoiding hepatic and splenic clearance due to its optimized nanoscale size [102]

Clinical trials reached phase II before the program was discontinued

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