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Persistent vomiting or diarrhea: If you can't keep fluids down for more than 24 hours or have severe diarrhea, you risk dehydration and need medical evaluation

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For people with chronic kidney disease, protein intake should be individualised with guidance from a healthcare professional or dietitian

Compare that to the estimated sublingual absorption of large peptide molecules, which even optimistic projections place between 5 and 15 percent for most compounds without specialized permeation enhancers

However, its bioavailability, tissue specificity, and long-term safety still need further optimization