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severe renal impairment (CrCl 10 000-fold preference for PDE5 over PDE1-4 and 700-fold over PDE11
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We've seen interesting data using infusions of tevogrumab (anti-myostatin) +/- garetosmab (anti-activin A) in combo with #semaglutide (data will also be presented at #ADA2025 ) Bimagrumab: an ActRII blocker with a unique mechanism Inhibits myostatin and activins Increases lean muscle mass while decreasing fat mass Phase 2 Data (JAMA Netw Open, 2021) In adults with T2D and obesity: Fat mass: 20.5% Lean mass: 3.6% Body weight: 6.5% Waist: 9 cm HbA1c: 0.76% BELIEVE Study (NCT05616013) A Phase 2b RCT evaluating: Bimagrumab (currently infusion) vs placebo Alone or with #semaglutide In adults with BMI 30 or 27 with complications Results due at #ADA2025 later this month NCT06643728 A Phase 2 RCT evaluating: Bimagrumab (SUBCUTANEOUSLY) vs placebo Alone or with #tirzepatide In adults with BMI 30 or 27 with complications over 70w Expected completion Jan 2027 If BELIEVE confirms bimagrumabs effects, we may soon have the first anti-obesity drug that builds muscle
2021, article 125.
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