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Abbreviations %: Proportion of subjects AIC: Akaike information criterion AUC: Area under the curve BP: Blood pressure bpm: Beats per minute CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration CI: Confidence interval CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial DPP-4i: Dipeptidyl peptidase-4 inhibitor eGFR: Estimated glomerular filtration rate exenatide ER: Exenatide extended release GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA 1c : Glycated hemoglobin HF: Heart failure HR: Hazard ratio JP: Japanese trial LDL-C: Low-density lipoprotein cholesterol MACE: Major adverse cardiovascular events MI: Myocardial infarction Mono: Monotherapy n: Number of subjects with events N: Number of subjects in full analysis set NNT: Number needed to treat to avoid one MACE during 1 year NYHA: New York Heart Association OAD: Oral antidiabetes drug Q: Quartile SBC: Schwarz Bayesian Information Criterion SBP: Systolic blood pressure SD: Standard deviation SE: Standard error SGLT-2i: Sodium-glucose co-transporter-2 inhibitor T2D: Type 2 diabetes References: Novo Nordisk

Retatrutide is a triple agonist peptide targeting GIP, GLP-1, and glucagon receptors simultaneously