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Identifying additional risk factors to enhance cancer prevention efforts is an area of intensive research (79)

They may increase the risk of side effects or change the effectiveness of either or both substances

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Family members may need professional help in coping with this problem

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy