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In The Lancet 2023 trial (Frias et al.), once weekly co administration (CagriSema) was reported to result in greater weight loss than semaglutide alone or cagrilintide alone , with tolerability described within the protocol context
The same caution applies to combining it with any other GLP-1 or incretin agent: doing so compounds the class effects and the class risks, and there is no documented protocol for it
Day 7: Left knee crepitus (the crunchy feeling) felt reduced during warm-up sets
In SURPASS-1 monotherapy over 40 weeks, blood sugar below 54 mg/dL occurred in 0% of tirzepatide users across all three doses versus 1% on placebo
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