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The appetite-suppressing effect in the brain appears more durable than the stomach-slowing effect, but the early, very palpable sense that food simply isnt interesting does tend to soften over time
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In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]
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