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If Grade 2 nausea persists despite pausing escalation, or if vomiting occurs, the dose should be reduced to the last well tolerated dose rather than discontinued

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The goal is to reduce avoidable muscle loss and support body composition

Similarly, protein and enzymatic assessments of ETC complexes in the postmortem prefrontal cortex showed that levels of the ETC complex I subunit and complex I activity were decreased significantly in patients with BD compared with nonpsychiatric individuals [48]

[7] [2] In the SURPASS clinical trial program for type 2 diabetes, the most frequently reported side effects were gastrointestinal in nature