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Second-generation inhibitors such as valspodar offered improved potency but interfered with CYP450 enzymes (e.g., CYP3A4), leading to problematic drugdrug interactions

Increased Training Capacity Improved recovery can allow athletes to: Tolerate higher training volumes Maintain intensity across longer training cycles Reduce cumulative fatigue This indirect effect is likely more impactful than any direct ergogenic benefit

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Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males

Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor