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Everything in this section is extrapolation based on the mechanism of action and user-reported outcomes

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The pattern in patient reviews: those reporting substantial weight loss (10+ pounds in 4 weeks) invariably mention concurrent dietary changes, increased exercise, or use of other medications (metformin, GLP-1 agonists)

RER is affected by feeding status, activity, stress, circadian phase, non-steady-state conditions, acid-base balance, and experimental methodology