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It is a mitochondrial-derived peptide encoded by mitochondrial DNA
NAD + -Related Signaling Considerations NAD + is both a redox cofactor and a signaling-related metabolite used by NAD + -dependent enzyme families such as sirtuins, poly(ADP-ribose) polymerases, CD38, and CD157
Clinical Response: Doctors might change the dose based on how well the patient is doing
US Patent US5538945A provides intellectual history but not clinical evidence
Cell Host Microbe 26 (2), 265-272.e4
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