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Zhu X, et al
only 9% of placebo-treated patients, achieving statistical significance ( P = 0.019)
That human review is a key reason appeals can succeed
However, given the TMAO elevating effect of oral L-carnitine supplementation, whether or not L-carnitine is a reasonable therapy to reduce Lp(a) levels requires further long-term investigations with hard clinical endpoints such as AMI, stroke and mortality risks
Carrillo-Vico A, Lardone PJ, Naji L et al (2005) Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects
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