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Gradual, Steady Progress Weight loss with GLP-1 medications tends to be gradual and sustained when combined with healthy lifestyle habits

In consideration of the reduced compliance of peptide GLP-1 receptor agonists due to subcutaneous injection, oral micromolecular GLP-1 receptor agonists such as orforglipron have already in clinical trials, which can reduce body weight and improve cardiac metabolism in adults with obesity (Wharton et al 2023) (Fig

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The BROAD study: a randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes

Adding AOD 9604 targeted fat breakdown may shift this ratio even further toward preferential fat loss, though controlled studies of the combination are limited