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However, TrxR is inactivated by MQ and converted to an NADPH oxidase that produces ROS 15

The delayed gastric emptying characteristic of these therapies frequently causes gastrointestinal adverse effects, particularly nausea, vomiting, and diarrhea

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Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]

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