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Nevertheless, owing to the numerous GLP-1 receptors expressed in several tissues in the human body, it not surprising that the pleiotropic effects of GLP-1 RA have been identified

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Spatial transcriptomics confirmed that regions with high Sphingosine kinase 1 (SPHK1) expression closely correlate with the spatial distribution of M2-like macrophages, while inhibiting S1P synthesis reverses their pro-angiogenic phenotype (328)

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