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This imbalance renders granulosa cells vulnerable to ferroptosis, which can impair estrogen synthesis and disrupt follicular development ( - expression and promoting lipid peroxidation, ultimately triggering ferroptosis ( Notably, androgen excess, a hallmark of PCOS, may also contribute to ferroptosis

And so it is important that these medications are prescribed in the setting of a comprehensive weight management program so that patients can do the other parts of healthy weight management to maintain their health and their muscle mass