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"All these little changes that you're making, you're losing more and more weight and you feel like you're able to do more." Medication doesn't replace diet or exercise Rothenhoefer said the biggest thing she wants people to understand about taking tirzepatide and other weight-loss medications is that doing so is a serious, long-term decision, not a magic potion

Epigenetics 8 , 730738, (2013)

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Providing an average weight reduction of 20.9% in clinical trials, Zepbound could be a potent choice for those who haven't responded comprehensively to other treatments