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The life expectancy for MVA patients is very often compromised

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[237] but, based upon the clinical use of carbonic anhydrase inhibitors, carbonic anhydrase activation in other tissues may be associated with adverse effects, such as ocular activation exacerbating glaucoma

Furthermore, studies evaluating the histological progression of MASLD severity over time using paired liver biopsies have found a lower likelihood of fibrosis regression among active smokers (e.g., only 4% regression compared to 12% progression) [63]