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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2

Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, et al

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Later than 24 h, catalase, GR and GP activity were still prone to be higher in proline group with the significantly higher activity of GR at 48 h

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