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Capsules may appeal to patients who want convenience, while injections are often discussed for more direct delivery

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According to the 2025 meta-analysis by Alfalasi and colleagues, sublingual B12 showed an approximate 199% mean increase in serum B12 compared to approximately 307% for intramuscular injections

It is used for the management of pain, local anesthesia, and various medical procedures requiring anesthesia

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