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Semaglutide is FDA-approved for adults with a BMI of 30 or higher (obese), or a BMI of 27 or higher (overweight) with at least one weight-related health condition such as high blood pressure, type 2 diabetes, or high cholesterol

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Even when clinical criteria are met, many regional BCBS plans classify Wegovy as a lifestyle medication rather than a medical necessity, placing it in higher cost-sharing tiers with substantial copayments or coinsurance obligations

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Retatrutide targets three hormone receptors (GLP-1, GIP, and glucagon), while Ozempic targets one (GLP-1) and Mounjaro targets two (GLP-1 and GIP)