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Anytime patients tell me they have a reaction from taking B vitamins, like nausea or some kind of digestive symptom, I automatically think that they might have some microbial issue

10.1016/j.jtbi.2005.07.003

The immunology of the vermiform appendix: A review of the literature

Patients with severe systemic lupus erythematosus who are ineffective on immunosuppressants can combine bortezomib and steroids, which are well tolerated and effective in long-term use[73]