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cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients
doi: 10.1158/1535-7163.MCT-06-0407 5 LongYTsaiWBChangJTEstecioMWangpaichitrMSavarajNet al
Reactive tests answer "what's wrong right now." Monitoring tests answer, "what am I at risk of?" Preventative tests answers, what is improving?
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