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Coming Off and Maintenance Semaglutide suppresses appetite but does not reset the biology that resists weight loss
It was discontinued in 2008 due to manufacturing issues (not safety concerns) and is still available through compounding pharmacies
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A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)
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