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Natural substances like berberine have shown promise in curbing obesity by blocking fat cell formation and altering gut microbiota, but their effectiveness is limited by low bioavailability [2]

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Microsphere production Microspheres were produced by a modified reverse emulsion polymerization method [13]

Lilly's NEJM-published phase 2 study showed: 17.5% mean weight reduction at 24 weeks with the highest dose 24.2% mean weight reduction at 48 weeks with the highest dose Dose-dependent improvement in glycemic markers GI side effects that were common but usually manageable That was the moment the molecule stopped looking like a clever concept and started looking like a serious obesity drug candidate