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Both forms ultimately provide vitamin B activity, but hydroxocobalamins longer duration in the body means injections can be given less frequently in maintenance therapy
Bioavailability of B12 is dependent on specific conditions in the digestive tract
Hydroxocobalamin has a longer half-life and is often used in Europe (e.g
FAD is a required cofactor for MTHFR
Specifically, the higher dose was associated with a 45% lower decline in ALSFRS-R scores and a delay in the need for full ventilation support or death by nearly two years compared with a placebo
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