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Ipamorelins selectivity for GH release over cortisol, ACTH, and prolactin co-stimulation is conferred primarily by its Aib (-aminoisobutyric acid) substitution a non-natural alpha-methyl amino acid that constrains the peptide backbone conformation in a manner that optimises GHS-R1a engagement at somatotrophs while reducing interactions with GHS-R1a expressing hypothalamic CRH neurons responsible for ACTH/cortisol co-stimulation
However, during acute MS relapses, excessive release of proinflammatory mediators may impair PRLM synthesis and function, resulting in defective resolution
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Eur J Endocrinol (2012) 167(5):65162.10.1530/EJE-12-0236 21 PellegriniIRasolonjanaharyRGunzGBertrandPDelivetSJedynakCPet alResistance to bromocriptine in prolactinomas
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