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Most patients regain significant weight within 1 year of stopping without behavioral support (STEP 1 extension data)
For patients wondering about fatigue during dose changes, the tirzepatide and fatigue guide explains what to expect and how to manage energy levels
Potential interactions have been reported in the literature involving diabetes medications, blood pressure medications, and certain other drugs
It becomes more likely as diabetes lasts longer, glucose control remains poor, and other risk factorssuch as hypertension and kidney diseaseaccumulate
and excluding Ueda/Wadden et al
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