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It reduces blood glucose levels and stimulates GLP-1 secretion via a G-protein mediated pathway, while also enhancing the insulin secretion through the modulation of ATP-dependent potassium channel thereby increasing calcium influx from intracellular reserves

The research framing discusses defined multi-week blocks commonly in the range of roughly 812 weeks followed by an off period before repeating, with the aim of limiting receptor down-regulation

Bomfim TR, Forny-Germano L, Sathler LB, et al

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