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Key tips for underwriting applicants with GLP1 use Immediately look for: Evidence of the underlying diagnosis (as seen in medical claims, EHR, APS) Whether the GLP-1 is FDA-approved or off-label for that condition Signs of medication adherence (12 months, regular fills) Get cautious when: A GLP1 appears without any supporting clinical context Fills are intermittent or recently initiated Theres no alignment between the medication and expected companion therapies (e.g., no CPAP with sleep apnea) Be confident when: The diagnosis is clear The drug is first line and clinically appropriate Use has been stable long enough to confer benefit Kyle Schimek, PharmD Kyle Schimek is a board-certified pharmacist and Clinical Services Manager at Milliman IntelliScript

GLP-1, GIP, and glucagon each regulate distinct but interconnected signaling networks associated with nutrient sensing, cellular metabolism, and endocrine communication

When reconstituted in bacteriostatic water and stored at 2-8C, TB-500 is typically considered stable for up to 28 days

The medications all work similarly, so practical access matters more than theoretical superiority

Roles for glutathione transferases in plant secondary metabolism