semaglutide vs glipizide oral antidiabetic drugs pharmacology • ⭐ Metformin = first-line • ⭐ Sulfonylureas → hypoglycemia • ⭐ TZDs → heart failure risk • ⭐ SGLT2 → UTI + weight loss • ⭐ α-glucosidase inhibitors → GI side effects • ⭐ DPP-4 inhibitors → safe, no Cardiovascular Risks Resurface Old Concerns
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