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Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models
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They also support a healthy nervous system and promote the production of red blood cells
These studies typically apply the complex in a controlled injury model and score closure, tensile properties of the repaired tissue, histology and matrix composition
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