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doi:10.1073/pnas.1216100110 10
this warrants ongoing monitoring No unexpected serious cardiovascular signals were identified during the limited Phase 2 follow-up period, though the trials were neither designed nor powered to assess cardiovascular outcomes, and longer-term data are not yet available At present, the overall safety profile appears broadly consistent with other GLP-1-based therapies, but definitive conclusions cannot be drawn until Phase 3 data and post-marketing surveillance are available
GLP-1RAs are an effective option for managing weight gain and metabolic complications in patients with psychiatric disorders without serious adverse events
The effects appear cumulative: each session reinforces the previous one
These structural modifications reduce affinity for endogenous IGF binding proteins, resulting in altered stability and interaction characteristics in experimental systems compared to native IGF-1
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