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Renal impairment GLP-1 RAs are generally safe in patients with CKD and have demonstrated nephroprotective effects in the FLOW trial, where semaglutide significantly reduced the composite renal endpoint (hospitalization for acute kidney injury, sustained 50% decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or renal death) in patients with type 2 diabetes and CKD [15]
For future studies, it would be of interest to investigate whether aging or certain pathological conditions could impair MuSC functions via disruption of the Keap1/Nrf2 axis
Veterinarski Arhiv 90:5768
& Wei, C
