does semaglutide cause kidney problems can disease Long-term outcomes of in obesity and cardiovascular in the SELECT trial Ozempic May Help Treat Kidney There have been reports of

Alruwaili H, Dehestani B, le Roux CW

The other is your individual mix of risk factors, like smoking, sleep apnea, or chronic obstructive pulmonary disease (COPD), that add to your risk of a dangerous clot, says Calvert

From an insurance perspective, side effects matter because dose adjustments or treatment interruptions can complicate ongoing prior authorizations

Whats more, a recent retrospective, multicenter cohort study denied higher occurrence of nonarteritic anterior ischemic optic neuropathy (NAION) in GLP-1RAs users and suggested that its potential benefits for blood glucose control and cardiovascular health likely outweigh its risks (Chou et al., 2025), despite that a few research have reported association between semaglutide prescription and a higher risk of NAION(61)

Neither medication is clearly safer than the other