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In addition to its role as a cellular antioxidant, because it is present in such high amounts, glutathione also functions as a thiol buffer, maintaining the sulfhydryl groups of many cellular proteins in their reduced form

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Minor criteria are (1) foot deformities including broad/plump forefoot, brachydactyly with excessive skin, pes planus, hallux valgus, and piezogenic papules

Goonathilake et al., 2022), reflecting widespread PDE4 expression in immune, gastrointestinal, and neural tissues