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Common Side Effects GLP-1 medications often cause gastrointestinal (GI) issues , especially when starting treatment: 1

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Key aims of the female protocol include: Developing the first rigorously data-driven female longevity protocol Investigating whether fertility can be improved through targeted interventions Exploring whether perimenopause onset can be slowed Identifying approaches to alleviate premenstrual symptoms Investigating suspected endometriosis non-invasively (endometriosis affects an estimated 1 in 10 reproductive-age women globally, approximately 190 million people, yet has historically required surgery to diagnose (23) How Blueprint XX Differs from Johnson's Protocol Tolo is referred to internally as Blueprint XX - a designation that underscores that the female protocol is not simply a copy of Johnson's

The most well-known examples, apart from pioglitazone, are fenofibrate, pemafibrate, seladelpar, elafibranor and lanifibranor, which have been studied in various trials regarding their effect on liver inflammation and fibrosis, without particular success, with the exception of lanifibranor, a pan-PPAR agonist, which was shown in a phase 2b RCT (NATIVE-NCT03008070) to improve ballooning and inflammation, without worsening of fibrosis

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