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Following a review completed in 2024, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) concluded that available evidence did not support a causal link between GLP-1 receptor agonists and suicidal ideation or self-harm, a conclusion also reflected in MHRA communications that year

The Bottom Line Retatrutide and Mounjaro are related through their GIP and GLP-1 receptor activity, but they are different molecules with different regulatory positions

It releases inflammatory signals and hormones that can lead to insulin resistance, higher cortisol, and a sluggish metabolic rate

JA: Project administration, Supervision, Writing review & editing, Conceptualization, Funding acquisition, Writing original draft

Lopez G, Torres K, Liu J, Hernandez B, Young E, Belousov R, et al