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Body weight-based scaling does not translate linearly across specieshuman doses of 23mcg/kg are not equivalent to rodent doses, which require 50100 higher per-kilogram amounts (100300mcg/kg) to produce comparable GH secretion peaks
These steps help keep experiments comparable over time when using LC-216 Peptide in sequential study phases
This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]
[PMCID:PMC11043712]
For Scientific American, this is Kendra Pierre-Louis
