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Typical nasal spray dosing: Concentration: 0.10.5% solution Dose per actuation: 100 mcg500 mcg depending on formulation Frequency: 12 actuations per nostril, 12 times daily Nasal administration may offer particular advantages for the cognitive and neuroprotective applications of GHK-Cu, as the nasal-olfactory pathway provides a direct route to the central nervous system
In turn, this sped up the healing of intestinal ulcers
This opens protocol design options and raises mechanistic questions about how a 15-amino-acid peptide survives the GI tract with sufficient intact molecule to produce systemic effects (or whether the observed effects are primarily local GI-tract actions)
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