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Abstract Glucagon-like peptide-1 receptor agonists are a class of drugs that mimic a natural incretin hormone released by the intestine after meals, and they are well-suited for treating type 2 diabetes
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Studies show 2539% of weight lost on GLP-1 medications is lean body mass roughly a decade of aging-related muscle loss compressed into months
Following the GRADE criteria, the limitations result in a low-to-very-low certainty rating, indicating that current evidence is insufficient to establish a causal relationship and that future research may substantially affect our confidence in the effect estimate (Fig 2)
GLP-1s include blockbuster diabetes medicines such as Ozempic and its weight-loss spinoff, Wegovy
